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pH Control in Bioreactors

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pH is an important parameter to control in bioprocessing, because most cell types and organisms have a quite narrow pH optimum. Here you can find a wealth of information on how to set up effective pH control systems in bioreactors, as well as the different aspects to consider.

Principle of pH control in bioprocesses

In bioprocessing, maintaining a narrow pH range is often required to ensure maximum productivity. However, fluctuations in pH are a common occurrence. This can be due to several factors including cell growth, temperature, CO2 levels, and lactic acid production. An effective pH control system ensures that the pH doesn’t fall outside of the optimal range. This requires the use of accurate pH sensors, connected to a control system that can initiate the calculated injection of an acid or base to adjust the pH. Effective pH control in bioreactors has a number of considerations - from the type and calibration of pH sensors, to which acid and base to use, and which bioprocess control software to choose. See below for expert knowledge on pH control in bioreactors, providing you with the information you need to design a pH control system tailored towards your bioprocessing needs.

What different types of pH sensors are available?

Electrochemical pH sensors‌

Optical pH sensors‌

What are digital pH sensors ?‌

pH control strategies

What acid and base should I use for pH control in microbial and cell cultures?‌

What is a pH deadband?‌

What is the difference between one-sided and two-sided pH control?‌

How do you calibrate a pH sensor?

Electrochemical pH sensor calibration‌

Optical pH sensor calibration‌

How frequently should you calibrate pH sensors?‌

How strong is the influence of temperature for your pH calibration?‌

Your pH sensor take ages to calibrate, what can you do?‌

Bioprocess control systems for streamlined pH control in bioreactors

Eppendorf has a range of bioprocess control systems suitable for both microbial and mammalian cell cultures. They offer high flexibility in pH control. Most systems are compatible with standard electrochemical as well as optical pH sensors and can be used with digital as well as analog sensors. Each bioprocess controller also has the ability to control a range of additional parameters such as temperature and dissolved oxygen , enabling streamlined bioprocess control tailored towards your bioprocessing needs.

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